A NETWORK-BASED APPROACH TO INTEGRATE NUTRIENT MICROENVIRONMENT IN THE PREDICTION OF SYNTHETIC LETHALITY IN CANCER METABOLISM.

A network-based approach to integrate nutrient microenvironment in the prediction of synthetic lethality in cancer metabolism.

Synthetic Lethality (SL) is currently defined as a type of genetic interaction in which the loss of function of either of two genes individually has limited effect in cell viability but inactivation of both genes simultaneously leads to cell death.Given the profound genomic aberrations acquired by tumor cells, which can be systematically identified

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Ethical and social implications of approaching death prediction in humans - when the biology of ageing meets existential issues

Abstract Background The discovery of biomarkers of ageing has led to the development of predictors of impending natural death and has paved the way for personalised estimation of the risk of death in the general population.This study intends to identify the ethical resources available to approach the idea of a long-lasting dying process and conside

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Diagnostic Value of Preoperative Electrodiagnostic Analysis in a Patient with Facial Palsy and a Large Vestibular Schwannoma: Case Report

Face mask Although radiologic methods confirm the diagnosis of patients with large vestibular schwannomas, these methods usually indicate only the size of the tumor and its possible nerve compression.Electrodiagnostic methods can reveal the functional state of the nerves, particularly the trigeminal and facial nerves, as well as providing a basis f

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